easy way to fix the problem: 1. Update vCenter to version 4U1; 2. Update all nodes of all clusters to version 4U1; 3. Run the command “esxcfg-advcfg -s 1 / VMFS3 / FailVolumeOpenIfAPD” on ALL nodes of ONE of the clusters; 4. By connecting-disconnecting the test LUN, make sure that the problem is resolved; 5. In case of successful elimination of the problem on one cluster, apply the above setting on the nodes of the remaining clusters;