As Calvin Coolidge said

Nothing to do.

Talent will not; nothing is more common than unsuccessful people with talent. Genius will not; unrewarded genius is almost a proverb. Education will not; the world is full of educated derelicts.
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Persistence and determination alone are omnipotent. The slogan "press on"

Or in Russian:

Nothing can replace perseverance: neither talent — nothing is more ordinary than talented losers, nor genius — the genius-loser has already entered the proverb, no education — the world is full of educated outcasts.

Almighty only persistence and perseverance. The motto "push up / do not give up" solved and will always solve the problems of mankind.

(c) Calvin Coolidge, 30th President of the United States