
The “secrets of life” can be discovered with a new microscope, which was
created at FEI . This microscope is recently installed at
Monash University , Melbourne, Australia. A cryoelectron microscope is able to show scientists the
molecular structure of various types of tissue in very high resolution. According to the head of the project, Professor James Whistock, working with such a system is a joy for a scientist.
Wiscestock hopes that the microscope (its name is FEI Titan Krios) will help to better study diseases such as various types of cancer, diabetes and multiple sclerosis. The study of these diseases is required to understand the mechanism of the emergence and existence of the disease in order to find a cure for treatment.
“Understanding our immune system is a key factor in the fight against cancer, infectious diseases such as malaria, and autoimmune diseases, including diabetes and multiple sclerosis. The key to understanding and curing these diseases is knowing how proteins and cells interact at the molecular level, ”says the professor.
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The principle of operation of the device is “bombarding” with a beam of high-energy electrons of a sample frozen in liquid ethane at a temperature of about 200 degrees below zero. Some electrons are reflected or absorbed by the molecules of the sample substance. Reflected beams allow you to create a two-dimensional map of the sample. A compilation of a large number of 2D photos, allows you to create three-dimensional models.
The cost of the project to create such a microscope was 5 million US dollars. The size of the device is 3 meters (in height), it is an extremely complex system that really allows you to see molecular structures.