Scientists have found a way to "turn off" neuropathic pain
Scientists have discovered a possible way to block neuropathic pain in the brain in animals caused by chemotherapeutic agents and bone cancer. The discovery can affect the elimination of this type of pain in humans.
Neuropathic pain results from the pathological excitation of neurons in the nervous system, which are responsible for the usual pain that occurs as a response to physical impact. Scientists have demonstrated that stimulating the A3 adenosine receptor in the brain and spinal cord eliminates pain without causing addiction, unlike opioids.
Pain is a huge problem, as it causes not just a bad mood, but also a loss of performance. The bulk of modern ways to stop pain has similar effects, including the body's addiction to drugs and the need to increase the dose to get the effect. The most successful approaches work with “pathways” in the nervous system: these are calcium channel blockers, opioid receptors and adrenoreceptors.
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Adenosine already had potential as a painkiller for humans, but scientists have so far worked very little with this method, since exposure to adenosine receptors can cause a huge amount of side effects. New research has shown that activation of the A3 receptor in the brain and spinal cord of rodents prevents pain from nerve damage - a source of chronic pain.
The experiment was carried out on Sprague Dawley rats and Salvatore mice. Animals were damaged by nerves, causing various types of chronic pain, and then treated with effects on the A3 receptors. Adenosine kinase inhibitor ABT-702 was able to save the animals from pain. Now it's up to the small: test the performance of the method on living people.
Neuropathic pain results from the pathological excitation of neurons in the nervous system, which are responsible for the usual pain that occurs as a response to physical impact. Scientists have demonstrated that stimulating the A3 adenosine receptor in the brain and spinal cord eliminates pain without causing addiction, unlike opioids.
Pain is a huge problem, as it causes not just a bad mood, but also a loss of performance. The bulk of modern ways to stop pain has similar effects, including the body's addiction to drugs and the need to increase the dose to get the effect. The most successful approaches work with “pathways” in the nervous system: these are calcium channel blockers, opioid receptors and adrenoreceptors.
')
Adenosine already had potential as a painkiller for humans, but scientists have so far worked very little with this method, since exposure to adenosine receptors can cause a huge amount of side effects. New research has shown that activation of the A3 receptor in the brain and spinal cord of rodents prevents pain from nerve damage - a source of chronic pain.
The experiment was carried out on Sprague Dawley rats and Salvatore mice. Animals were damaged by nerves, causing various types of chronic pain, and then treated with effects on the A3 receptors. Adenosine kinase inhibitor ABT-702 was able to save the animals from pain. Now it's up to the small: test the performance of the method on living people.
Source: https://habr.com/ru/post/363589/
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