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How to do it? In Safari 4 (here - the Windows version) an interesting menu item appeared:

This simple way erases the differences between web and desktop applications :)
Also in Safari 4 client-side SQL from the HTML5 draft is implemented - for storing data on the client by such web applications.
There is a widespread opinion that in the future the OS will be one big browser. I think this is not so - just the web services themselves will be deeper and more interesting to integrate with the OS, bypassing the browser.
PS there is Mozilla Prism, offering similar functionality